(HealthDay News) – Supplementation with resveratrol, a compound found in red wine, negates positive health effects of exercise training in older men, according to a study published online July 22 in The Journal of Physiology.

Lasse Gliemann, from the University of Copenhagen in Denmark, and colleagues randomized 27 healthy, physically inactive aged men (age, 65 years; body mass index, 25.4kg/m²; mean arterial pressure [MAP], 95.8mm Hg; maximal oxygen uptake, 2,488ml O2min−1) to eight weeks of daily intake of either 250mg trans-resveratrol or placebo along with high-intensity exercise training.

The researchers found that exercise training lead to a significant 45% greater increase in maximal oxygen uptake in the placebo group compared to in the resveratrol group. There was also a significant decrease in MAP in the placebo group only (−4.8mmHg). In the resveratrol group the interstitial level of vasodilator prostacyclin was lower than in the placebo group after training (980 vs. 1,174pgml−1; P<0.02). Muscle thromboxane synthase was higher in the resveratrol group after training (P<0.05). The positive effects of exercise (on low-density lipoprotein levels, total cholesterol/high-density lipoprotein ratio, and triglyceride concentrations in blood) were significantly reversed with resveratrol administration. Resveratrol supplementation did not affect sirtuin 1 protein levels.

“These findings indicate that, whereas exercise training effectively improves several cardiovascular health parameters in aged men, concomitant resveratrol supplementation blunts most of these effects,” the authors write.

Fluxome provided trans-resveratrol and placebo tablets for the study.

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