Prezcobix, a combination of an HIV-1 protease inhibitor and a CYP3A inhibitor, is indicated to treat HIV-1 infection in adults.
Under the Drug Interactions section, the following updates have been made:
- Prednisone has been added as an alternative corticosteroid to consider for co-administration with Prezcobix especially for long-term use
- Dose recommendations for HMG-CoA reductase inhibitors: daily doses for atorvastatin and rosuvastatin should not exceed 20mg.
- When coadministering Prezcobix with drospirenone (hormonal contraceptive), clinical monitoring is recommended due to potential for hyperkalemia.
- Concomitant administration with ticagrelor, a platelet aggregation inhibitor, is not recommended.
In addition, clinically relevant interactions have not been observed or are not anticipated with concomitant use of rilpivirine, dolutegravir, raltegravir, abacavir, emtricitabine, emtricitabine/tenofovir alafenamide, tenofovir DF, lamivudine, stavudine, zidovudine, or acid modifying medications (eg, antacids, H2-receptor antagonists, proton pump inhibitors).
Prezcobix is available as 800mg/150mg strength tablets in 30-count bottles.
For more information call (800) 526-7736 or visit Prezcobix.com.