HealthDay News — For women with type 1 diabetes, elevated fatty acid binding protein 4 (FABP4) in early pregnancy and in the second trimester is associated with subsequent preeclampsia, according to a study published online September 14 in Diabetes Care.

Amy C. Wotherspoon, from Queen’s University in Belfast, U.K., and colleagues measured serum FABP4 in 710 women from the Diabetes and Pre-eclampsia Intervention Trial in early pregnancy (median 14 weeks of gestation) and in the second trimester (median 26 weeks of gestation). 

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The researchers found that in women in whom preeclampsia later developed, FABP4 was significantly elevated in early pregnancy and the second trimester (both P<0.001). There was an independent association for elevated second-trimester FABP4 level with preeclampsia (odds ratio, 2.87; P=0.03). At both time points, the addition of FABP4 to established risk factors significantly improved net reclassification improvement, and integrated discrimination improvement in the second trimester.

“Increased second-trimester FABP4 independently predicted preeclampsia and significantly improved reclassification and discrimination,” the authors write. “FABP4 shows potential as a novel biomarker for preeclampsia prediction in women with type 1 diabetes.”

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