Nuvo Research announced the launch of Pennsaid (diclofenac sodium; Mallinckrodt) topical solution 2% w/w. Pennsaid 1.5% w/w has been available since 2010, and the new 2% strength was approved in January 2014.

Pennsaid 2% is a nonsteroidal anti-inflammatory drug (NSAID) indicated for the treatment of osteoarthritis pain of the knee. Diclofenac inhibits the enzyme, cyclooxygenase (COX), an early component of the arachidonic acid cascade, resulting in the reduced formation of prostaglandins, thromboxanes and prostacylin.

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Pennsaid 2% solution is more viscous than the 1.5% strength. It is now available in a 112g metered dose pump bottle that delivers 20mg of diclofenac sodium in 1g of solution per pump actuation.

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