HealthDay News — Ivermectin (IVM) has anti-inflammatory properties that could be beneficial in treatment of T-cell mediated skin inflammatory diseases, according to an experimental study published online January 4 in Allergy.

Erwan Ventre, PhD, from the Université de Lyon in France, and colleagues examined the activity of IVM in a murine model of atopic dermatitis induced by repeated exposure to Dermatophagoides farinae and in cellular immunology assays. 

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The researchers found that topical IVM correlated with improvement in allergic skin inflammation, with reduction of the priming and activation of allergen-specific T cells and the production of inflammatory cytokines. IVM had no major effect on dendritic cell functions in vivo and in vitro, but following polyclonal and antigen-specific stimulation, IVM did impair T-cell activation, proliferation, and cytokine production.

“Altogether, our results show that IVM is endowed with topical anti-inflammatory properties that could have important applications for the treatment of T-cell mediated skin inflammatory diseases,” the authors write.

Several authors were employed by Galderma, which manufactures ivermectin and funded the study.

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