Ozempic (semaglutide injection) and Fiasp (insulin aspart injection), two recently-approved diabetes treatments, are now available in U.S. pharmacies, according to Novo Nordisk.
Ozempic, a once-weekly glucagon-like peptide (GLP-1) receptor agonist, is indicated as an adjunct to diet and exercise to improve glycemic control in adults with type 2 diabetes; it is intended for subcutaneous injection. Semaglutide reduces blood glucose through a mechanism where it stimulates insulin secretion and lowers glucagon secretion, both in a glucose-dependent manner. Thus, when blood glucose is high, insulin secretion is stimulated and glucagon secretion is inhibited.
Fiasp, a fast-acting mealtime insulin, is indicated to improve glycemic control in adults with type 1 and type 2 diabetes; it is intended for subcutaneous injection or intravenous infusion. Receptor-bound insulin lowers blood glucose by facilitating cellular uptake of glucose into skeletal muscle and adipose tissue and by inhibiting the output of glucose from the liver. Insulin inhibits lipolysis in the adipocyte, inhibits proteolysis, and enhances protein synthesis.
Ozempic is available as 0.5mg and 1mg strength injections in single-patient-use pens that deliver 0.25mg, 0.5mg, or 1mg per injection. Fiasp 100 units/mL is available in 10mL multi-dose vials and in 3mL single-patient-use FlexTouch pens.