GlaxoSmithKline announced that the FDA has approved Flonase Allergy Relief (fluticasone propionate 50mcg spray) as a once-daily over-the-counter (OTC) treatment indicated for symptoms of seasonal and perennial allergic and nonallergic rhinitis in patients ≥4 years of age. Flonase Allergy Relief contains the same active ingredient and the same dosage strength as prescription Flonase (also from GlaxoSmithKline).

Fluticasone propionate is a synthetic trifluorinated corticosteroid with anti-inflammatory activity. The precise mechanism of action of fluticasone propionate is not known, but corticosteroids have been shown to have a wide range of effects on multiple cell types (eg, mast cells, eosinophils, neutrophils, macrophages, lymphocytes) and mediators (eg, histamine, eicosanoids, leukotrienes, cytokines) involved in inflammation.

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Flonase Allergy Relief will be available OTC in early 2015.

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