HealthDay News — One night of sleep deprivation is associated with amyloid-β (Aβ) burden (ABB) in healthy controls, according to a study published online April 9 in the Proceedings of the National Academy of Sciences.

Using positron emission tomography and 18F-florbetaben, Ehsan Shokri-Kojori, PhD, from the National Institutes of Health in Bethesda, Maryland, and colleagues measured brain ABB in 20 healthy controls tested after a night of rested sleep (baseline) and a night of sleep deprivation. 

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The researchers found that relative to baseline, 1 night of sleep deprivation resulted in a significant increase in ABB in the right hippocampus and thalamus. These increases were associated with mood worsening after sleep deprivation; however, they were not associated with the genetic risk for Alzheimer’s disease (APOE genotype). There was an inverse association for baseline ABB in a range of subcortical regions and the precuneus with reported night sleep hours. There was also a correlation for APOE genotyping with subcortical ABB.

“Our findings show adverse effects of 1-night sleep deprivation on brain ABB and expand on prior findings of higher Aβ accumulation with chronic less sleep,” the authors write.

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One author was an employee of Piramal Pharma, which partially supported the radiotracer for the study.

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