The use of nonsteroidal anti-inflammatory drugs (NSAIDs) may be associated with an increased risk of atrial fibrillation (AF) for some patients, according to a study published in the British Journal of Clinical Pharmacology.
For this study, researchers from Taiwan aimed to determine the link between NSAID use and the risk of AF particularly in a middle-aged Asian population. They performed a nested case-control study using data from the National Health Insurance Research Data (NHIRD) in Taiwan by extracting cases and matched controls from 2001 to 2013 (N=57,058).
The analysis showed an increased risk of AF for NSAID users vs non-users (adjusted odds ratio [aOR] 1.18, 95% CI: 1.14–1.23). Specifically, the use of non-selective NSAIDs (aOR 1.18, 95% CI: 1.13–1.23) and combined selective and non-selective NSAIDs (aOR 1.30, 95% CI: 1.21–1.39) was associated with a significantly higher risk of AF.
“Based on the findings from this study, benefits and risks of NSAID use should be carefully evaluated when delivered in clinical practice,” said senior author Dr. Hui-Ju Tsai.
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