Novel Pig Model to Study Inherited Arrhythmia Developed

The first large animal model of an inherited arrhythmic syndrome has been developed by researchers at NYU Langone Medical Center. Findings have been published in The Journal of Clinical Investigation.

The genetically engineered pig sodium channelopathy model will allow scientists to better understand the underlying biologic mechanisms and the treatment investigation for inherited life-threatening arrhythmias, which can cause sudden cardiac death. Prior to the development of this novel model, researchers had been using cultured heart cells and mouse models to study arrhythmias.

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Scientists anticipate that possible future therapies, such as drugs enhancing the cardiac sodium channel expression or radiofrequency ablation procedures, can be tested in the pig model prior to patient administration.

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