Aerie announced that the Food and Drug Administration (FDA) has approved Rhopressa (netarsudil ophthalmic solution) for the reduction of elevated intraocular pressure in patients with open-angle glaucoma or ocular hypertension.

Rhopressa, a rho kinase inhibitor, is believed to reduce intraocular pressure by increasing the outflow of aqueous humor through the trabecular meshwork route. The product was evaluated in 3 randomized and controlled clinical trials: Study 301, Study 302, and Study 304. Studies 301 and 302 evaluated patients with baseline intraocular pressure <27mmHg whereas Study 304 evaluated patients with baseline intraocular pressure <30mmHg. 

Findings from the 3 studies showed up to a 5mmHg reduction in intraocular pressure for patients treated with Rhopressa 0.02% once daily in the evening. For patients with baseline intraocular pressure <25mmHg, the reductions were similar between the Rhopressa 0.02% and timolol 0.5% treatment groups. For patients with baseline intraocular pressure ≥25mmHg, the reductions at the morning time points were smaller in the Rhopressa group vs the timolol group for study visits on Days 43 and 90. 

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The most common adverse reactions associated with Rhopressa are conjunctival hyperemia, cornea verticillata, instillation site pain, and conjunctival hemorrhage.

Rhopressa 0.02% ophthalmic solution will be available as a 2.5mL fill in a 4mL container. It is anticipated to launch by the middle of the second quarter of 2018. 

For more information call (908) 470-4320 or visit