HealthDay News — Normalized blood pressure (BP) is associated with an increased risk for all-cause mortality for older adults during hypertension treatment, with increased risk seen in octogenarians and those with previous cardiovascular events, according to a study recently published in the European Heart Journal.

Antonios Douros, MD, from the Universitätmedizin Berlin, and colleagues examined the correlation of BP values less than 140/90mmHg during antihypertensive treatment with the risk for all-cause mortality in a cohort of 1628 patients aged ≥70 years.

The researchers found that 636 of the patients exhibited normalized BP. Overall, 469 patients died during 8853 person-years of follow-up. Normalized BP (<140/<90mmHg) correlated with an increased risk for all-cause mortality compared with non-normalized BP (≥140/≥90 mm Hg; incidence rates, 60.3 vs 48.5 per 1000 person-years; hazard ratio, 1.26). Risks were increased in patients aged ≥80 years (102.2 vs 77.5 per 1000 person-years; hazard ratio, 1.40) and in patients with previous cardiovascular events (98.3 vs 63.6 per 1000 person-years; hazard ratio, 1.61). Risks were not increased among patients aged 70 to 79 years or for those without previous cardiovascular events.

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“Given the scarcity of randomized controlled trials in elderly populations and the challenges regarding the generalization of their results in real-world clinical practice, careful individualized clinical assessment of potential benefits, and harms of antihypertensive treatment should guide physician decision-making,” the authors write.

Several authors disclosed financial ties to the pharmaceutical industry.

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