A new tool would allow children to be assessed quickly and accurately for their risk of death due to septic shock, according to a study published January 29 in PLOS ONE. This tool, known as PERSEVERE, measures five biomarkers and analyzes this with information about the patient to determine the probability of mortality due to septic shock.
Based on a multi-institutional study led by Hector Wong, MD, from the Cincinnati Children’s Hospital Medical Center, and Christopher Lindsell, PhD, from the University of Cincinnati College of Medicine, 182 pediatric patients from intensive care units of 17 pediatric institutions were tested using the tool. Patients were tested within 24 hours of admission to the intensive care units and ranged from ages 1–13 with a variety of conditions and severity of illnesses.
Results showed that children who tested positive for high-risk sepsis had a 34% chance of not surviving, compared to 3% for those who tested negative. Twenty-one percent of patients tested positive but survived the infection. While these patients had greater degrees of organ failure and extended intensive care stays compared to those who tested negative, the researchers emphasize that the patients likely survived due to the treatments they received once indicated as high-risk by the test.
The research team is continuing to use the diagnostic tool in studies on critical care for children, as well as in adult populations.
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