HealthDay News — mRNA-based SARS-CoV-2 vaccines appear to be immunogenic in patients receiving immunosuppressive medications for the management of chronic inflammatory disease (CID), according to a study published online August 31 in the Annals of Internal Medicine.

Parakkal Deepak, MBBS, from the Washington University School of Medicine in St. Louis, and colleagues determined the immunogenicity of mRNA-based SARS-CoV-2 vaccines in a volunteer sample of adults with confirmed CID who were eligible for early COVID-19 vaccination and immunocompetent participants recruited among hospital employees. Antibody responses were assessed following the 2-dose vaccination series.

The researchers found that 88.7% of 133 participants with CID and all 53 immunocompetent participants developed antibodies in response to mRNA-based SARS-CoV-2 vaccination; numerically lower titers of anti-S IgG developed in some with CID. After vaccination, anti-S IgG antibody titers were lower in those with CID receiving vs those not receiving glucocorticoids; the geometric mean of anti-S IgG antibodies was 357 and 2190 for those receiving and not receiving prednisone, respectively. Those receiving B-cell depletion therapy also had lower anti-S IgG antibody titers.

“Most patients with CID receiving immunosuppressive treatment were able to mount antibody responses, which provides justification for current recommendations for this population to be vaccinated,” the authors write.

One author disclosed financial ties to Pfizer.

Abstract/Full Text