HealthDay News — Magnesium levels, either too high or too low, are associated with an increased risk of dementia, according to a study published online September 20 in Neurology.
Brenda C.T. Kieboom, MD, from the Erasmus MC-University Medical Center Rotterdam in the Netherlands, assessed serum magnesium levels in 9,569 participants in the Rotterdam Study, who were free from dementia at baseline (1997 to 2008). Participants (mean age, 64.9 years; 56.6% women) were followed until January 1, 2015, to determine incident dementia.
The researchers found that over a median follow-up of 7.8 years, 823 participants were diagnosed with all-cause dementia. There was an increased risk of dementia associated with both low serum magnesium levels (≤0.79 mmol/L) and high serum magnesium levels (≥0.90 mmol/L) (hazard ratios, 1.32 and 1.30, respectively).
“As we are the first to study this association, our results warrant replication in other population-based studies,” the authors write.