HealthDay News — Results from a pragmatic randomized, double-blind clinical trial indicate that milrinone and dobutamine yield similar outcomes in the treatment of cardiogenic shock, according to a study published in the August 5 issue of the New England Journal of Medicine.

Rebecca Mathew, MD, from the University of Ottawa Heart Institute in Canada, and colleagues randomly assigned patients with cardiogenic shock to receive milrinone (96 patients) or dobutamine (96 patients). Comparisons were made with respect to a composite primary outcome of in-hospital death from any cause, resuscitated cardiac arrest, receipt of a cardiac transplant or mechanical circulatory support, nonfatal myocardial infarction, transient ischemic attack or stroke diagnosed by a neurologist, or initiation of renal replacement therapy.

The researchers found that the primary outcome was similar between the 2 groups (49% in the milrinone group and 54% in the dobutamine group; relative risk [RR], 0.90; 95% CI, 0.69 to 1.19; P =.47). Results were similar when looking at individual components, including in-hospital death (RR, 0.85; 95% CI, 0.60 to 1.21), resuscitated cardiac arrest (hazard ratio [HR], 0.78; 95% CI, 0.29 to 2.07), receipt of mechanical circulatory support (HR, 0.78; 95% CI, 0.36 to 1.71), or initiation of renal replacement therapy (HR, 1.39; 95% CI, 0.73 to 2.67).

“In contrast to our hypothesis, we did not find a significant advantage of milrinone over dobutamine with respect to the composite primary outcome or secondary outcomes,” the authors write.


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One author disclosed financial ties to the medical technology industry.

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