After 28 days of citicoline supplementation, adolescent males showed statistically significant increased motor speed, improved attention, and decreased impulsivity in research published in the Journal of Attention Disorders.

The double-blind, placebo-controlled study enrolled 75 healthy adolescent males and randomly  assigned them to daily citicoline supplementation (250mg or 500mg) or placebo for 28 days. Participants completed the Ruff 2&7 Selective Attention Test, Finger Tap Test, and the Computerized Performance Test, Second Edition (CPT-II) at baseline and after 28 days of supplementation.

Males receiving citicoline had improved attention (P=0.02) and increased psychomotor speed (P=0.03) compared to those receiving placebo after 28 days. A higher weight-adjusted dose significantly predicted increased accuracy on an attention task (P=0.01), improved signal detectability on a computerized attention task (P=0.03), and decreased impulsivity (P=0.01).

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Lead author Deborah Yurgelun-Todd, PhD, added that although dopamine was not measured in this study, the effects of citicoline supplementation may be due to increased dopamine activity. In previous studies citicoline has led to increased levels of dopamine, which may be one of the mechanisms through which citicoline improves motor and attentional functions.

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