HealthDay News — Caffeinated beverage consumption early in the second trimester (within current guidelines of less than 200mg per day) is associated with a lower risk for gestational diabetes and a favorable cardiometabolic profile versus no consumption, according to a study published online November 8 in JAMA Network Open.

Stefanie N. Hinkle, PhD, from the University of Pennsylvania in Philadelphia, and colleagues conducted a post hoc analysis using data from the US National Institute of Child Health and Human Development Fetal Growth Studies-Singletons (2009 to 2013) to examine the impact of caffeine on maternal health. The analysis included 2802 pregnant women without major chronic conditions participating at 12 US clinical sites.

The researchers found that at 10 to 13 gestational weeks, 41.5% of women reported consuming no caffeinated beverages; 51% reported consuming 1mg/day to 100mg/day; 6.7% reported 101mg/day to 200mg/day; and 0.8% reported great than 200mg/day. Caffeine consumption tended to increase at 16 to 22 weeks, with estimates of 23.6, 68.3, 7.3, and 0.8% consuming no caffeinated beverages, 1mg/day to 100mg/day, 101mg/day to 200mg/day, and greater than 200mg/day, respectively. Caffeine intake at 16 to 22 weeks was associated with lower gestational diabetes risk and lower glucose concentrations (1mg/day to 100mg/day vs none: relative risk, 0.53; β, −2.7mg/dL), lower C-reactive protein and C-peptide concentrations, and favorable lipid profiles. There were no associations observed between caffeine intake and preeclampsia or gestational hypertension (GH).

“Second trimester caffeinated beverage intake within current recommendations was associated with lower GDM risk, but not preeclampsia or GH,” the authors write. “These findings may be reassuring for women with moderate caffeine intake.”

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