HealthDay News — Regular long-term aspirin use is associated with a dose-dependent reduction in the risk for hepatocellular carcinoma (HCC), according to a study published online October 4 in JAMA Oncology.

Tracey G. Simon, MD, from Massachusetts General Hospital in Boston, and colleagues examined the potential benefits of aspirin use for primary HCC prevention in 2 prospective, nationwide populations: the Nurses’ Health Study and the Health Professionals Follow-up Study. Data were included for 133,371 health care professionals who reported on aspirin use, frequency, dosage, and duration of use. 

Related Articles

The researchers documented 108 incident HCC cases over more than 26 years of follow-up encompassing 4,232,188 person-years. Regular aspirin use (two or more 325mg tablets per week) was correlated with reduced HCC risk compared with non-regular use (adjusted hazard ratio, 0.51; 95% confidence interval, 0.34 to 0.77). This benefit was dose-related (P for trend = 0.006). With increasing duration, there was significantly lower HCC risk (P=.03); the decrease was seen with use of 1.5 or more standard-dose tablets per week for five or more years (adjusted hazard ratio, 0.41; 95% confidence interval, 0.21 to 0.77). There was no significant association for use of non-aspirin non-steroidal anti-inflammatory drugs with HCC risk (adjusted hazard ratio, 1.09; 95% confidence interval, 0.78 to 1.51).

“Further research appears to be needed to clarify whether aspirin use represents a feasible strategy for primary prevention against HCC,” the authors write.

One author disclosed financial ties to the pharmaceutical industry.

Abstract/Full Text