Kynmobi Now Available to Treat Off Episodes in Parkinson Disease

Kynmobi™ (apomorphine HCl sublingual film; Sunovion) is now available for the acute, intermittent treatment of off episodes in patients with Parkinson disease (PD). The treatment was approved in May 2020 based on results from a phase 3 trial that demonstrated significant improvements in motor symptoms.

Apomorphine is believed to treat off episodes associated with PD through stimulation of postsynaptic dopamine D2-type receptors within the caudate-putamen in the brain. The product, which is supplied as a sublingual film in 10mg, 15mg, 20mg, 25mg, and 30mg dosage strengths, is designed for use as a fast-acting, on-demand treatment for all types of motor off episodes.

Dose initiation and titration of Kynmobi should occur when the patient is in an off state and in a setting where a healthcare provider can monitor blood pressure and pulse, as syncope and hypotension may occur. As the drug may cause nausea and vomiting, an antiemetic (trimethobenzamide 300mg; 3 times daily) is recommended beginning 3 days prior to the initial dose. The administration of antiemetic drugs other than trimethobenzamide has not been studied and Kynmobi is contraindicated with concomitant use of 5HT₃ antagonists. Additionally, oral mucosal irritation may occur with treatment and could require pausing or discontinuing therapy.

The most common adverse reactions reported with Kynmobi included nausea, oral/pharyngeal soft tissue swelling, oral/pharyngeal soft tissue pain and paraesthesia, dizziness, and somnolence. Additional prescribing information can be found here.

For more information visit kynmobi.com.

Reference

Sunovion announces the commercial launch of KYNMOBI™ (apomorphine hydrochloride) sublingual film for the treatment of parkinson’s sdisease OFF episodes. https://www.businesswire.com/news/home/20201005005482/en/Sunovion-Announces-the-Commercial-Launch-of-KYNMOBI%E2%84%A2-apomorphine-hydrochloride-Sublingual-Film-for-the-Treatment-of-Parkinson%E2%80%99s-Disease-OFF-Episodes. Accessed October 5, 2020.