The FDA has approved Juvéderm XC (hyaluronic acid and lidocaine [preservative-free] injectable gel, from Allergan) dermal filler for injection into the mid-to-deep dermis for correction of moderate to severe facial wrinkles and folds (eg, nasolabial folds). Juvéderm XC is formulated with 0.3% preservative-free lidocaine to reduce the need for an additional anesthetic.  This approval was based on data from a multicenter, double-blind, randomized clinical trial conducted in 72 patients. Patients were followed for two weeks after treatment with Juvéderm XC or Juvéderm, which contains no lidocaine. In the study, 93% of patients reported less pain when treated with Juvéderm XC compared to those treated with Juvéderm.

Juvéderm XC is available in two formulations as Juvéderm Ultra XC and Juvéderm Ultra Plus XC.

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