Novartis announced that the Food and Drug Administration (FDA) has approved Jadenu (deferasirox) tablets for the treatment of chronic iron overload due to blood transfusions in patients ≥2 years old, and for chronic iron overload in non-transfusion-dependent thalassemia syndromes (NTDT) in patients ≥10 years old.
Jadenu is the new oral formulation of Novartis’ Exjade (deferasirox) tablets for oral suspension. Deferasirox is an orally-active chelator that is selective for iron (as Fe3+). It is a tridentate ligand that binds iron with high affinity in a 2:1 ratio. Although deferasirox has very low affinity for zinc and copper there are variable decreases in the serum concentration of these trace metals after the administration of deferasirox.
Jadenu was approved under accelerated approval based on data demonstrating the reduction of liver iron concentrations and serum ferritin levels. It will be available as an oral, film-coated tablet in 90mg, 180mg, and 360mg strengths in 30-count bottles.
For more information call (888) 669-6682 or visit Jadenu.com.