Although prior research has supported the efficacy of statins as a treatment for asthma, questions regarding drug delivery to the lungs when taken orally. In this study, scientists developed a new method to measure statin levels in mice after treatment with inhaled statins and improvement in asthma symptoms. When administered as a spray, the drug was found to be nontoxic and delivered primarily to the lungs; the treatment reduced the airway’s sensitivity to allergens, had modest anti-inflammatory effects, and lowered overproduction of mucus in mice.
While the optimal statin type and dose for treating asthma in humans has yet to be determined, the authors conclude that statins should be explored as a novel class of inhaler therapy in humans trials involving asthma patients.
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