A novel “stepped care” treatment approach was effective in improving blood pressure control among patients with severe intolerance to antihypertensives, a study published in the Journal of Clinical Hypertension reported.

Study authors from the Queen Mary University of London and Barts Health NHS Trust developed a treatment strategy that involved fractional dosing with tablets (splitting pills into halves or quarters), liquid and patch formulations of antihypertensive medications, plus use of unlicensed drugs that reduce blood pressure. The “stepped care” approach utilizes the most effective yet least intensive treatment to the patients first.

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In their study of 55 patients, blood pressure was significantly decreased after six months on the treatment strategy and was sustained. Researchers found that this personalized treatment approach enabled patients to tolerate a higher number of medications and led to significant and longer lasting reduction in blood pressure.

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