HealthDay News — For HIV-infected women, anti-müllerian hormone is associated with age of menopause onset, according to a study published in the January issue of the American Journal of Obstetrics & Gynecology.

Rebecca Scherzer, PhD, from the University of California, San Francisco, and colleagues examined the correlation between anti-müllerian hormone and age of menopause onset in 2,461 HIV-infected women. The authors identified factors associated with age at final menstrual period in multivariable normal mixture models for censored data. 

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The researchers found that even after multivariable adjustment for smoking, CD4 cell count, plasma HIV RNA, hepatitis C infection, and history of clinical AIDS, higher anti-müllerian hormone at age 40 years correlated with later age at final menstrual period. There was a 1.5-year increase in the age at final menstrual period for each doubling of anti-müllerian hormone. The median age at final menstrual period varied from 45 to 52 years for those in the 10th and 90th percentiles of anti-müllerian hormone, respectively. There were independent associations for smoking, hepatitis C infection, higher HIV RNA levels, and history of clinical AIDS with earlier age at final menstrual period.

“Measuring anti-müllerian hormone in HIV-infected women may enable clinicians to predict risk of early menopause, and potentially implement individualized treatment plans to prevent menopause-related comorbidities and to aid in interpretation of symptoms,” the authors write.

Two authors disclosed financial ties to the pharmaceutical and medical device industries.

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