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HealthDay News — Treatment with haloperidol does not yield a greater number of days alive and out of the hospital at 90 days than placebo among patients with delirium admitted to the intensive care unit, according to a study published online October 26 in the New England Journal of Medicine to coincide with LIVES 2022, the annual congress of the European Society of Intensive Care Medicine, held from October 22 to 26 in Paris.
Nina C. Andersen-Ranberg, MD, from Zealand University Hospital in Køge, Denmark, and colleagues randomly assigned 1000 adult patients with delirium who had been admitted to the intensive care unit for an acute condition to receive haloperidol or placebo (510 and 490, respectively). Of these patients, 501 and 486, respectively, were included in the final analyses.
The researchers found that the mean number of days alive and out of the hospital at 90 days was 35.8 and 32.9 in the haloperidol and placebo groups, respectively (adjusted mean difference, 2.9 days; 95% CI, −1.2 to 7.0; P =.22). Ninety-day mortality was 36.3 and 43.3% in the haloperidol and placebo groups, respectively (adjusted absolute difference, −6.9 percentage points; 95% CI, −13.0 to −0.6). Serious adverse reactions occurred in 11 and 9 patients in the haloperidol and placebo groups, respectively.
“The use of haloperidol did not lead to a significantly greater number of days alive and out of the hospital at 90 days than placebo,” the authors write.
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