Guidelines

Strong recommendations made for use of polyethylene glycol, sodium picosulfate, linaclotide, plecanatide, and prucalopride.

The time-based deferrals for men who have sex with men (MSM) and women who have sex with MSM have been eliminated.

The new guideline aims to limit toxicity and improve cancer control and survival in patients with UTUC.

Current evidence is insufficient for assessing balance of benefits and harms of screening asymptomatic adults, adolescents.

Guideline suggests use of biomarker- and symptom-based monitoring strategy over symptom-based strategy for patients in symptomatic remission.

Pulmonary function tests may be beneficial every six months, may be of use in initiating noninvasive ventilation when indicated

Risk-based testing recommendations expanded to include people who are or were incarcerated, those with history of sexually transmitted infections

Data were synthesized from animal models, medical countermeasure use for human cases of related OPXV, input from experts, experience during consultations

Daily supplement of 0.4 to 0.8 mg recommended for people planning to or who could become pregnant

Strong recommendation made against long-term opioid therapy, especially for younger age groups, those with substance use disorder