Espero announced the launch of GoNitro (nitroglycerin) sublingual powder for acute relief of an attack or prophylaxis of angina pectoris due to coronary artery disease.

GoNitro is a short-acting nitrate formulated in a patented, stabilized crystal granule. Each single-dose packet contains 400mcg of nitroglycerin, which is comparable to commonly dispensed strengths of nitroglycerin as a sublingual spray and sublingual tablet. The sublingual absorption of nitroglycerin was higher after administration of GoNitro vs. nitroglycerin lingual spray in clinical studies. 

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Nitroglycerin is a vasodilator that forms free radical nitric oxide, which activates guanylate cyclase, resulting in an increase of guanosine 3′, 5′-monophosphate (cyclic GMP) in smooth muscle and other tissues. This eventually leads to dephosphorylation of myosin light chains, which regulates the contractile state in smooth muscle and results in vasodilation.

GoNitro is supplied as cartons containing 36 individual packets.

For more information call (800) 235-6520 or visit