HealthDay News — Among individuals with the strongest genetic predisposition to elevated intraocular pressure (IOP), greater caffeine consumption is associated with higher IOP and higher glaucoma prevalence, according to a study published in the June issue of Ophthalmology.

Jihye Kim, PhD, from the Harvard T. H. Chan School of Public Health in Boston, and colleagues examined the association of habitual caffeine intake with IOP and glaucoma, as well as if genetic predisposition to higher IOP altered these associations. Analysis included 121,374 participants in the UK Biobank (baseline ages, 39 to 73 years) with data collected from 2006 to 2010.

The researchers found that Mendelian randomization analysis did not find a causal effect of coffee drinking on IOP. Greater caffeine intake was associated weakly with lower IOP, with the highest (232mg/day or more) vs lowest (less than 87mg/day) caffeine consumption associated with a 0.10 mm Hg lower IOP. However, this association was modified by IOP polygenic risk score (PRS): Among participants in the highest IOP PRS quartile, consuming more than 480mg/day vs less than 80mg/day was associated with a 0.35 mm Hg higher IOP. There was no relationship observed between caffeine intake and glaucoma. Again, the IOP PRS modified this association, with those in the highest IOP PRS quartile consuming 321mg/day or more showing a 3.90-fold higher glaucoma prevalence, compared to those in the lowest IOP PRS quartile consuming no caffeine.

“This study suggested that those with the highest genetic risk for glaucoma may benefit from moderating their caffeine intake,” a coauthor said in a statement. “It should be noted that the link between caffeine and glaucoma risk was only seen with a large amount of caffeine and in those with the highest genetic risk.”


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Several authors disclosed financial ties to the pharmaceutical and biotechnology industries.

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