Digoxin is a cardiac glycoside indicated in adult patients for the treatment of mild to moderate heart failure and for ventricular rate control in chronic atrial fibrillation. In pediatric patients, it is indicated for increasing myocardial contractility in heart failure.
Digoxin inhibits Na+/K+ ATPase, an enzyme that regulates the quantity of sodium and potassium inside cells.
Inhibition of the enzyme leads to an increase in the intracellular concentration of sodium and thus (by stimulation of sodium-calcium exchange) an increase in the intracellular concentration of calcium.
Digoxin tablets are available in 0.125mg and 0.25mg strengths.
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