Voriconazole is a triazole antifungal indicated for invasive aspergillosis, nonneutropenic candidemia, candida infections in abdomen, kidney, bladder, wounds, or skin (disseminated), esophageal candidiasis, and serious infections caused by Scedosporium apiospermum and Fusarium species in patients refractory to, or intolerant of, other agents.
Its primary mode of action is the inhibition of fungal cytochrome P-450-mediated 14 alpha-lanosterol demethylation, an essential step in fungal ergosterol biosynthesis. The accumulation of 14 alpha-methyl sterols correlates with the loss of ergosterol in the fungal cell wall and may be responsible for the antifungal activity.
Voriconazole for Oral Suspension is available in a 40mg/mL dosage strength.
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