Malarone is indicated for the prophylaxis of Plasmodium falciparum malaria and the treatment of acute, uncomplicated P. falciparum malaria. Atovaquone and Proguanil HCl interfere with 2 different pathways involved in the biosynthesis of pyrimidines required for nucleic acid replication. Atovaquone is a selective inhibitor of parasite mitochondrial electron transport. Proguanil HCl primarily exerts its effect by means of the metabolite cycloguanil, a dihydrofolate reductase inhibitor. Inhibition of dihydrofolate reductase in the malaria parasite disrupts deoxythymidylate synthesis.
Atovaquone Proguanil HCl is available in 62.5mg/25mg and 250mg/100mg strength tablets. Mylan has started shipping the product.
For more information call (800) 796-9526 or visit Mylan.com.