Fosphenytoin Sodium, a hydantoin, is indicated for the control of generalized tonic-clonic status epilepticus and for the prevention and treatment of seizures occurring during neurosurgery. Fosphenytoin Sodium can also be substituted, short-term, for oral phenytoin. It should be used only when oral phenytoin administration is not feasible; it must not be given orally.
Fosphenytoin is a prodrug of phenytoin and its anticonvulsant effects are attributable to phenytoin. It is thought to work by modulating voltage-dependent sodium channels of neurons, inhibiting calcium flux across neuronal membranes, modulating voltage-dependent calcium channels of neurons, and enhancing sodium-potassium ATPase activity of neurons and glial cells.
Fosphenytoin Sodium Injection is available as 75mg/mL (50mg phenytoin sodium equivalents [PE]/mL), packaged in 100mg PE/2mL and 500mg PE/10mL single-use vials.
For more information call (800) RX-MYLAN or visit Mylan.com.