Nexium is a proton pump inhibitor indicated as triple therapy (w. amoxicillin + clarithromycin) for H. pylori eradication in duodenal ulcer disease; short-term treatment and maintenance of healing of erosive esophagitis (EE), symptomatic GERD; short-term treatment of EE due to acid-mediated GERD in infants 1 month–<1 year; to reduce risk of NSAID-associated gastric ulcer; and for long-term treatment of pathological hypersecretory conditions (eg, Zollinger-Ellison syndrome).
Esomeprazole works by suppressing gastric acid secretion by specific inhibition of the H+/K+-ATPase in the gastric parietal cell. By specifically acting on the proton pump, esomeprazole blocks the final step in acid production, thus reducing gastric acidity.
Esomeprazole Magnesium Delayed-Release Capsules are available in 20mg and 40mg strengths in 30-count bottles.
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