The generic version of Merck‘s cholesterol drug Vytorin has been made available by several generic manufacturers, including Teva and Impax

Vytorin is indicated as adjunct to diet in primary hyperlipidemia (heterozygous familial and non-familial) or mixed hyperlipidemia: to reduce elevated total-C, LDL-C, apo B, TG and non-HDL-C, and to increase HDL-C; and as adjunct to or when other lipid-lowering treatments for homozygous familial hypercholesterolemia (HoFH) are not available: to reduce elevated total-C and LDL-C. 

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Vytorin contains ezetimibe, a cholesterol absorption inhibitor, and simvastatin, an HMG-CoA reductase inhibitor. Ezetimibe lowers blood cholesterol by inhibiting the absorption of cholesterol by the small intestine. Simvastatin, a prodrug, is hydrolyzed to its active form, simvastatin acid. It inhibits the enzyme that catalyzes the conversion of HMG-CoA to mevalonate, an early and rate limiting step in the biosynthetic pathway for cholesterol.

Ezemtimibe and Simvastatin Tablets are available as 10/10mg, 10/20mg, 10/40mg, and 10/80mg strengths for both brands.

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