HealthDay News — For patients receiving concurrent chemoradiotherapy for squamous cell carcinoma of the head and neck, higher doses of gabapentin are well tolerated and associated with delayed time to first opioid use for additional pain control during radiotherapy (RT), according to a research letter published online May 18 in JAMA Network Open.

Sung Jun Ma, MD, from the Roswell Park Comprehensive Cancer Center in Buffalo, New York, and colleagues performed a secondary analysis of 2 clinical trials involving 92 patients receiving concurrent chemoradiotherapy for nonmetastatic squamous cell carcinoma of the head and neck and prophylactic oral gabapentin (titrated to 900mg versus 2700mg daily in one study and 3600mg daily in the other study).

The researchers found that most patients tolerated gabapentin per protocol. The time to first opioid use for additional pain control was greatest in the 3600-mg cohort in the multivariable competing risks model. The smallest proportion of patients requiring opioids during RT was seen in the 3600-mg cohort compared with the 900-mg and 2700-mg cohorts (37.5, 93.1, and 61.3%, respectively). Compared with the 3600-mg cohort, the odds of feeding tube placement were significantly greater during RT in the 2700-mg cohort; the odds were not significantly greater in the 900-mg cohort.

“Although gabapentin, 3600mg, daily has been adopted as the standard regimen of the Roswell Park Comprehensive Cancer Center, additional studies are warranted to further investigate its role in pain control,” the authors write.

Abstract/Full Text