HealthDay News—Frequent use of aspirin in patients ≥65 years is associated with early aging macular disorder (AMD) and wet late AMD, according to a study published in the January issue of Ophthalmology.

Paulus T.V.M. de Jong, MD, PhD, of the Netherlands Institute for Neuroscience and Academic Medical Center in Amsterdam, and colleagues investigated the correlation between aspirin use and early and later AMD. A structured questionnaire was used to determine aspirin intake and potential confounders for AMD among 4,691 participants, ≥65 years, in the population-based European Eye Study from seven centers. Standardized ophthalmic and basic systemic measurements were carried out, and the severity of AMD was graded according to the modified International Classification System using digitized fundus images.

The researchers found that early and late AMD were present in 36.4% and 3.3% of participants, respectively. Monthly, weekly, and daily aspirin use was reported by 42.1%, 7%, and 17.3% of participants, respectively. After adjusting for potential confounders, for daily aspirin users, there was a steady increase in the odds ratios (ORs) with increasing severity of AMD grades (OR for grade 1, 1.26; OR for grade 2, 1.42; and OR for wet late AMD, 2.22).

“Frequent aspirin use was associated with early AMD and wet late AMD, and the ORs rose with increasing frequency of consumption,” the authors write.

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