Coagadex (coagulation Factor X [human]; Bio Products Laboratory) is now available for patients ≥12 years old with hereditary Factor X deficiency for on-demand treatment and control of bleeding episodes, and perioperative management of bleeding in patients with mild hereditary Factor X deficiency.
Coagadex is the only specific Factor X concentrate available in the United States. It works by temporarily replacing the missing Factor X needed for effective homeostasis. Factor Xa, its active form, associates with Factor Va on a phospholipid surface to form the prothrombinase complex, which activates prothrombin to thrombin in the presence of calcium ions. Thrombin then acts upon soluble fibrinogen and Factor XIII to generate a cross-linked fibrin clot.
Coagadex will be available through specialty pharmacies and authorized distributors with specialized disease state and product training. It is supplied in single-use vials containing a nominal 250 IU or 500 IU Factor X activity.
For more information call (844) 4BPLUSA or visit Coagadex.com.