HealthDay News – Fecal microbiota transplantation (FMT) is effective for Clostridium difficile infection (CDI) through 6 months and has a good safety profile, according to a study published online October 1 in Gastroenterology.

Colleen R. Kelly, MD, from the Warren Alpert Medical School of Brown University in Providence, Rhode Island, and colleagues examined the safety and effectiveness outcomes of FMT using data from the FMT National Registry for patients across North America.

Of the first 259 participants, 222 completed follow-up at 1 month and 123 were followed for up to 6 months. The researchers found that all FMTs were performed for CDI and 96% used an unknown donor. Ninety percent had one-month cure; of these, 98% received only a single FMT. Four percent of the 112 with initial cure who were followed for 6 months had CDI recurrence. Within 1 month of FMT, severe symptoms included diarrhea and abdominal pain (2% each); 1% had hospitalization possibly related to FMT. There were new diagnoses of irritable bowel syndrome and inflammatory bowel disease in 1% each at 6 months.

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“These initial results show a high success rate of FMT in the real-world setting. We’ll continue to track these patients for 10 years to assess long-term safety, which will be critical to determining the full safety profile of FMT,” Kelly said in a statement.

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Several authors disclosed financial ties to the biopharmaceutical and nutrition industries.

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