Silvergate Pharmaceuticals announced that the FDA has approved Epaned (enalapril maleate) powder for oral solution to treat hypertension in patients >1 month old. The new liquid formulation enables accurate dosing for children who until now have relied on an adjusted adult dose.

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Enalapril is an ACE inhibitor that suppresses the renin-angiotensin-aldosterone system, which results in decreased plasma angiotensin II. This further leads to decreased vasopressor activity and decreased aldosterone secretion.

Epaned for Oral Solution is available in a bottle containing 150mg powder for reconstitution along with 150mL of Ora-Sweet SF diluent to provide a 1mg/1mL final concentration.

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