Sutro Biopharma announced that the Food and Drug Administration (FDA) has granted Orphan Drug designation for STRO-001 for the treatment of multiple myeloma.
STRO-001 targets CD74, which is a protein highly expressed in B-cell malignancies like multiple myeloma. This potential first-in-class antibody drug conjugate (ADC) was developed with the Company’s proprietary cell-free protein synthesis and site-specific conjugation platform called XpressCF+. The technology allows for the manufacturing of a highly optimized single molecular species within the product instead of the usual mixture of imprecisely conjugated antibodies that make up an ADC product designed by conventional cell-based platforms.
STRO-001 is being evaluated in a Phase 1 trial that includes separate dose escalation cohorts for multiple myeloma and B-cell lymphoma.
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