Astellas Pharma US, Inc announced the results of a pivotal phase 3 clinical trial for mirabegron, the first of a new class of compounds under development for the treatment of overactive bladder (OAB). Patients treated with mirabegron showed significant improvements in key OAB symptoms – urinary incontinence and frequency of micturition compared with placebo. These results were also associated with statistically significant improvements in patient reported outcomes.
Mirabegron is a potent and selective beta-3 adrenoceptor agonist. It activates beta-3 adrenoceptor on the detrusor muscle of the bladder to facilitate filling of the bladder and storage of urine.
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