Phase 2b study of tesetaxel for treatment of gastric cancer

Genta Incorporated announced that it has initiated a confirmatory Phase 2b trial of tesetaxel in patients with advanced gastric cancer. This trial is designed to confirm the efficacy results observed in a preliminary Phase 2a study of tesetaxel as second-line treatment of gastric cancer patients. It will enroll patients who have progressed on a single first-line chemotherapy regimen. Endpoints of the new Phase 2b study include response rate, durable response, disease control, progression-free survival, and safety.

Tesetaxel is a novel, orally absorbed, semi-synthetic taxane. Tesetaxel was developed with a goal of maintaining the high antitumor activity of the taxane drug class while eliminating infusion reactions associated with intravenous taxanes (eg, paclitaxel and docetaxel), reducing neuropathy, and increasing patient convenience.

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