Sangamo BioSciences announced that it has completed enrollment of its Phase 2b trial of SB-509 in patients with diabetic neuropathy (DN). This double-blind, placebo-controlled trial is expected to produce efficacy data in the second half of 2011.  Data generated previous studies suggests that SB-509 treatment results in statistically significant increases in nerve fiber density, nerve regeneration and an improvement in approvable end-points such as Neuropathy Impairment Score of the Lower Limb (NIS-LL) and sural nerve conduction velocity (sNCV).

SB-509 is a transcriptional activator of the gene encoding vascular endothelial growth factor-A (VEGF-A) for DN and other neurological indications including ALS.  

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