Phase 2b study of dapagliflozin for type 2 diabetes

Bristol-Myers Squibb and AstraZeneca announced the published results from their Phase 2b trial of dapagliflozin for treatment-naïve type 2 diabetes patients.  The results of this randomized, double-blind, placebo-controlled, parallel-group study of 389 patients (ages 18-79) demonstrated that dapagliflozin produced clinically meaningful reductions across all key glycemic measures studied [glycosylated hemoglobin level (HbA1c), fasting plasma glucose (FPG), and postprandial plasma glucose (PPG)], compared to placebo.

Dapagliflozin is a novel, selective, sodium glucose co-transporter2 (SGLT2) inhibitor that limits the amount of glucose that is reabsorbed and retained in the body, thereby leading to the excretion of glucose in the urine.

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