Anacor Pharmaceuticals announced that the first patient has been dosed in a Phase 2b trial of AN2728 for the treatment of psoriasis. This double-blind, randomized, vehicle-controlled trial plans to enroll 60 patients with mild to moderate plaque-type psoriasis who will be randomized to 2% AN2728 topical ointment or vehicle in a 2:1 ratio. Given its size, the trial is not designed to demonstrate statistical differentiation of AN2728 from vehicle, but to inform the size and design of the two planned pivotal Phase 3 trials for AN2728.

AN2728 is a boron-based small-molecule compound that inhibits the activity of phosphodiesterase-4 (PDE4), thereby reducing the production of TNF-alpha, IL-12, IL-23 and other pro-inflammatory cytokines that are the precursors of the inflammation associated with psoriasis.

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