Phase 2 study of ENB-0040 for the treatment of hypophosphatasia

Enobia Pharma announced completion of enrollment for its Phase 2 study of ENB-0040 for the treatment of hypophosphatasia. HPP is a rare genetic disease characterized primarily by defective bone mineralization caused by a deficiency in the enzyme tissue nonspecific alkaline phosphatase (TNSALP). This study is a randomized, open-label, multicenter, multinational, dose-ranging, concurrent control study that will evaluate the safety and efficacy of ENB-0040 in adolescents and adults with HPP.  The study is expected to be completed in the second half of 2011.

ENB-0040 is a subcutaneous enzyme replacement therapy of TNSALP fused to a bone-targeting peptide. It is designed to directly target TNSALP to the bone in order to correct the enzyme deficiency, which could lead to restoration of normal bone mineralization.

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