Eli Lilly and Company and Incyte Corporation announced results from a second Phase 3 trial with baricitinib in patients with rheumatoid arthritis. Baricitinib is a once daily, oral, selective JAK1 and JAK2 inhibitor.

The RA-BUILD study included patients with moderately-to-severely active rheumatoid arthritis who had an inadequate response to, or were intolerant of, at least one conventional disease-modifying antirheumatic drug (cDMARD). Patients received either one of two doses of once-daily baricitinib or placebo, in addition to their background therapy. The study met its primary endpoint of an improved ACR20 response rate compared to placebo after 12 weeks of treatment.

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Baricitinib is currently in Phase 3 clinical development for rheumatoid arthritis and Phase 2 development for psoriasis and diabetic nephropathy.

For more information visit Lilly.com or Incyte.com.