AbbVie announced that the FDA has granted Orphan Drug designation to ABT-414, an anti-epidermal growth factor receptor (EGFR) monoclonal antibody drug conjugate, being evaluated for patients with glioblastoma multiforme.

ABT-414 is designed to be stable in the bloodstream and only release the potent cytotoxic agent once inside targeted cancer cells.

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ABT-414 is currently under investigation for the treatment of patients with various cancer and tumor types. AbbVie has also initiated clinical trials evaluating the use of ABT-414 for the treatment of patients with squamous cell tumors.

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