Innocrin announced that the Food and Drug Administration (FDA) has granted Fast Track designation to seviteronel (VT-464) for the treatment of patients with metastatic castrate-resistant prostate cancer (CRPC).

Some patients with resistance after treatment with abiraterone, enzalutamide or both, might respond to seviteronel therapy based on strong preclinical and clinical evidence. Treatment-resistance with these agents represents a major unmet medical need, especially with the widespread use and the high cross-resistance of cancers seen in patients exposed to them.

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Seviteronel is an oral, once daily, selective CYP17 lyase inhibitor (target of abiraterone) and an androgen receptor (AR) blocker (target of enzalutamide).

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